Manchester United traveled to LASK Linz as they take on the host for the first leg of the round of 16.
The encounter was played behind closed doors in Austria due to Coronavirus infection that is fast spreading.
Manchester United is unbeaten in ten games in all competitions with the last win coming against their bitter rival Manchester City.
Chinese Super side Shanghai Shenhua on loan
The former Nigerian International drew the first blood for the Red Devils in the 28th minute of play after Bruno Fernandez pass to the striker on the edge of the box, he fired a half volley after into the back of the net.
Odion was signed in the January transfer market from the Chinese Super side Shanghai Shenhua on loan as a replacement for injured Marcos Rashford. The forward has lived up to his billings so far.
He would have scored his second for the night but only managed to hit the base of the post.
Ighalo opened his scoring account for United underway against Club Brugge at Old Trafford, adding two more to his record at Derby County in the FA Cup and continued his streak on Tonight.
The 30-year-old has now scored 4 goals in 7 appearances for Ole Gunnar Solskjar Side.
Daniel James got united their second goal, to end his goal drought.
Juan Mata joined the party in the 82 minutes of play, the Spaniard deserved a goal after his beautiful display tonight.
Mason Greenwood added the Icing on the cake to make the scoreline 4-0.
There was still time for Andreas Herrera to kill the game in the added time of the 90 minutes.
Advantage Manchester United as they take 5 goals back to Old Trafford in the second leg of the round of 16 against the Austrian.